| Chemical Properties |
White to light beige powder |
|
|
| Uses |
- racemic-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl ( (+/-)-BINAP ) is an essential role in the organic synthesis of enantioselective transformations catalyzed by the complexes of ruthenium, rhodium and palladium.
- It is also employed in palladium-catalyzed arylamine coupling in the preparation of demethylthiocholchines.
- used with Cu(II) to catalyze the addition of arylsulfonamides to styrenes and olefins.
|
|
|
| Reactions |
Phosphine Ligand Kit component.
- Useful ligand for palladium-catalyzed carbon-nitrogen bond formation.
- Useful ligand for rhodium-catalyzed C-C bond formation.
- Useful ligand for palladium-catalyzed intramolecular acylation of aryl bromides via C-H activation.
- Used in the preparation of Buchwald third generation precatalyst.
- Used in methoxy directed Rhodium migration.
- Used in Nickel catalyzed C-N cross-coupling reactions.
|
|
|
| Purification Methods |
Dissolve the enantiomer in toluene, wash it with 30% aqueous NaOH, three times with H2O, dry (Na2SO4), evaporate to ~15% of its volume and add an equal volume of degassed MeOH. Collect the solid, wash it with MeOH and dry it at 80o/0.005mm for 6hours. Recrystallise it from a 1:1 mixture of toluene/EtOH to optical purity (m 241-242o) [Takaya et al. Org Synth 67 20 1989]. [Noyori & Takaya Acc Chem Res 2 3 345 1990, Kitamura et al. Org Synth 71 1 1993, Takaya et al. Org Synth 72 74 1995, Kitamura et al. J Org Chem 57 4053 1992.] |
|
|
