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  • Product Name:   N,N,N',N'-Tetramethylazodicarboxamide
  • Synonyms:   AZODICARBOXYLIC ACID BIS[DIMETHYLAMIDE];DIAMIDE;DIAZINE-DICARBOXYLIC ACID BIS[N,N-DIMETHYLAMIDE];1,1'-AZOBIS(N,N'-DIMETHYLFORMAMIDE);1,1'-AZOBIS(N,N-DIMETHYLFORMAMIDE)
  • CAS No.:   10465-78-8
  • Molecular Formula:   C6H12N4O2
  • Molecular Weight :   172.19
  • Specification :   98%
  • Place of Origin:   China
  • Appearance :   
  • Document :   Download

Description of N,N,N',N'-Tetramethylazodicarboxamide



N,N,N',N'-Tetramethylazodicarboxamide Chemical Properties


Melting point  112 °C


storage temp.  −20°C


form  crystalline


color  yellow


InChIKey VLSDXINSOMDCBK-BQYQJAHWSA-N


CAS DataBase Reference 10465-78-8(CAS DataBase Reference)




Safety Information


Safety Statements  22-24/25


WGK Germany  3


RTECS  LQ1041000


4.10




N,N,N',N'-Tetramethylazodicarboxamide Usage And Synthesis


Description N,N,N’,N’-Tetramethylazodicarboxamide (also named as Diamide, TMAD) is a reagent used for the oxidization of thiols in proteins. It is used as a reagent in the Mitsunobu reaction in place of diethyl azodicarboxylate. It can be used to titrate protein gluotathiolation to discriminate from other protein modifications.


References N. S. Kosower, E. M. Kosower, Diamide: A oxidant probe for this, Methods in Enzymology, 1995, vol. 251, pp. 123133


Chemical Properties Yellow crystals




N,N,N',N'-Tetramethylazodicarboxamide Preparation Products And Raw materials


Raw materials Dichloromethane-->Triethylamine-->HYDRAZINE-->Dimethylcarbamoyl chloride -->Silver oxide


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