N,N,N',N'-Tetramethylazodicarboxamide Chemical Properties | |
Melting point | 112 °C |
storage temp. | −20°C |
form | crystalline |
color | yellow |
InChIKey | VLSDXINSOMDCBK-BQYQJAHWSA-N |
CAS DataBase Reference | 10465-78-8(CAS DataBase Reference) |
Safety Information | |
Safety Statements | 22-24/25 |
WGK Germany | 3 |
RTECS | LQ1041000 |
F | 4.10 |
N,N,N',N'-Tetramethylazodicarboxamide Usage And Synthesis | |
Description | N,N,N’,N’-Tetramethylazodicarboxamide (also named as Diamide, TMAD) is a reagent used for the oxidization of thiols in proteins. It is used as a reagent in the Mitsunobu reaction in place of diethyl azodicarboxylate. It can be used to titrate protein gluotathiolation to discriminate from other protein modifications. |
References | N. S. Kosower, E. M. Kosower, Diamide: A oxidant probe for this, Methods in Enzymology, 1995, vol. 251, pp. 123133 |
Chemical Properties | Yellow crystals |
N,N,N',N'-Tetramethylazodicarboxamide Preparation Products And Raw materials | |
Raw materials | Dichloromethane-->Triethylamine-->HYDRAZINE-->Dimethylcarbamoyl chloride -->Silver oxide |
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