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- Product Name: 9-Fluorenylmethyl chloroformate
- Synonyms: 1-(9-fluorenyl)methylchloroformate;chloro-formicacifluoren-9-ylmethylester;Formicacid,chloro-,fluoren-9-ylmethylester;RARECHEM FM OC 0001;9h-fluoren-9-ylmethyl chloroformate
- CAS No.: 28920-43-6
- Molecular Formula: C15H11ClO2
- Molecular Weight : 258.7
- Specification : 98%
- Place of Origin: China
- Appearance :
- Document : Download
Description of 9-Fluorenylmethyl chloroformate
| 9-Fluorenylmethyl chloroformate Chemical Properties | |
| Melting point | 62-64 °C(lit.) |
| Boiling point | 365.79°C (rough estimate) |
| density | 1.1780 (rough estimate) |
| refractive index | 1.5330 (estimate) |
| storage temp. | 2-8°C |
| solubility | dioxane: 0.1 g/mL, clear, colorless |
| form | Crystalline Powder |
| color | White to very pale yellow |
| Sensitive | Moisture Sensitive |
| BRN | 2279177 |
| CAS DataBase Reference | 28920-43-6(CAS DataBase Reference) |
| Safety Information | |
| Hazard Codes | C,T |
| Risk Statements | 34-20/21/22 |
| Safety Statements | 26-36/37/39-45-27 |
| RIDADR | UN 3261 8/PG 2 |
| WGK Germany | 3 |
| RTECS | LQ6250000 |
| F | 10-21 |
| HazardClass | 6.1 |
| PackingGroup | II |
| HS Code | 29159020 |
| 9-Fluorenylmethyl chloroformate Usage And Synthesis | |
| Chemical Properties | White to off white crystalline powder |
| Uses | 9-Fluorenylmethyl Chlorocarbonate is an N-Protecting agent for peptides research and was used for the pre-column derivatization of the biogenic amines (BAs) cadaverine (Cad), histamine (Him), octopami ne (Ocp), phenylethylamine (Pea), putrescine (Put), spermidine (Spd), spermine (Spm), tyramine (Tym). |
| Uses | N-protecting reagent for oligonucleotide and peptide syntheses |
| Uses | Reagent for the introduction of Fmoc-amino-protecting group, which is stable towards acids but is readily cleaved under mildly basic non-hydrolytic conditions. |
| Purification Methods | If the IR contains no OH bands (at ~3000 cm-1) due to the hydrolysis product 9-fluorenylmethanol, then purify it by recrystallisation from dry Et2O. IR (CHCl3) has a band at 1770 cm-1 (C=O), and the NMR (CDCl3) has at 4-4.6 (m 2H, CHCH2) and 7.1-7.8 (m, 8 aromatic H) ppm. The azide (FMOC-N3) has m 89-90o (from -1hexane) and IR (CHCl3) at 2135 (N3) and 1730 (C=O) cm , and the carbazate (FMOC-NHNH2) has m 171o(dec) (from nitromethane), IR (KBr) 3310, 3202 (NH) and 1686 (CONH) cm-1. [Caprino & Han J Org Chem 37, 3404 1972 , J Am Chem Soc 92 5748 1970, Koole et al. J Org Chem 59 1657 1989, Fürst et al. J Chromatogr 499 537 1990.] |
| 9-Fluorenylmethyl chloroformate Preparation Products And Raw materials | |
| Preparation Products | 2-Ethylpiperazine-->[2-[2-(Fmoc-amino)ethoxy]ethoxy]acetic acid-->FMOC-2-AMINONICOTINIC ACID-->3-(9H-FLUOREN-9-YLMETHOXYCARBONYLAMINO)-ISONICOTINIC ACID |
| Raw materials | 9-Fluorenemethanol |
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