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  • Product Name:   Propylphosphonic anhydride
  • Synonyms:   T3P/Propanephosphonic acid cyclic anhydride;2,4,6-Tripropyl-1,3,5,2,4,6-trioxatriphosphinane 2,4,6-trioxide;1-Propylphosphonic acid cyclic anhydride, 50+% w/w soln. in dichloroMethane;1-Propylphosphonic acid cyclic anhydride, 50 wt.% solution in ethyl acetate;PPACA
  • CAS No.:   68957-94-8
  • Molecular Formula:   C9H21O6P3
  • Molecular Weight :   318.18
  • Specification :   98%
  • Place of Origin:   China
  • Appearance :   
  • Document :   Download

Description of Propylphosphonic anhydride

Propylphosphonic anhydride Chemical Properties

Boiling point  65 °C

density  1.069 g/mL at 25 °C

refractive index  n20/D 1.418

Fp  25 °F

storage temp.  Flammables area

solubility  Miscible with dioxane, terahydrofuran, dimethyl formamide, polar and aprotic organic solvents.

form  Solution

color  Clear yellow to brownish

Sensitive  Moisture Sensitive

BRN  5079255

CAS DataBase Reference 68957-94-8(CAS DataBase Reference)

Safety Information

Hazard Codes  T,C,F

Risk Statements  61-20/21-34-67-66-11

Safety Statements  53-26-36/37/39-45-33-16

RIDADR  UN 2924 3/PG 3

WGK Germany  1



HazardClass  8

PackingGroup  II

Propylphosphonic anhydride Usage And Synthesis

  1. TP3 is an exceptional reagent for amide/peptide bond formation. The product is very easy to use and combines excellent reaction selectivity, low epimerization, high yields and high product purities.
  2. Conversions of acids and amides to nitriles under mild conditions.
  3. Synthesis of urea and carbamate derivatives.
  4. Formation of thioacids from N-protected amino acids and peptides. 

Chemical Properties Clear light yellow solution

Uses It is employed as an efficient promoter for the Lossen rearrangement to synthesis urea and carbamate derivatives.

Propylphosphonic anhydride Preparation Products And Raw materials

Raw materials Hydrochloric acid-->Thionyl chloride-->Phosphorus pentachloride-->Triethyl phosphite-->1-Bromopropane

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Product: Propylphosphonic anhydride

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