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  • Product Name:   1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride
  • Synonyms:   (3-dimethylaminopropyl)ethyl-carbodiimidmonohydrochloride;3-propanediamine,n’-(ethylcarbonimidoyl)-n,n-dimethyl-monohydrochloride;edap;edc(reagent);WSCD
  • CAS No.:   25952-53-8
  • Molecular Formula:   C8H18ClN3
  • Molecular Weight :   191.7
  • Specification :   98%
  • Place of Origin:   China
  • Appearance :   
  • Document :   Download

Description of 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride Chemical Properties

Melting point  110-115 °C(lit.)

density  0.877 g/mL at 20 °C(lit.)

refractive index  n20/D 1.461

storage temp.  −20°C

solubility  H2O: soluble1 gm/10 ml, clear to very slightly hazy, colorless to very faintly yellow

form  Crystalline Powder

color  White to off-white

Water Solubility  Soluble

Sensitive  Hygroscopic

BRN  5764110

Stability: Stable, but sensitive to moisture. Incompatible with strong acids, strong oxidizing agents, moisture.


CAS DataBase Reference 25952-53-8(CAS DataBase Reference)

EPA Substance Registry System 1,3-Propanediamine, N'-(ethylcarbonimidoyl)- N,N-dimethyl-, monohydrochloride(25952-53-8)

Safety Information

Hazard Codes  C,Xi

Risk Statements  34-36/37/38-41-37/38-20/21/22

Safety Statements  26-36/37/39-45-37/39-36

RIDADR  UN 2735 8/PG 3

WGK Germany  3

RTECS  FF2200000


Hazard Note  Irritant


HS Code  29252000

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride Usage And Synthesis

Chemical Properties White crystalline powder

Uses It is being used for the synthesis of amides. EDC.HCl is also used as a coupling agent in the preparation of esters from carboxylic acids using dimethylaminopyridine as the catalyst. It is water-soluble carbodiimide, widely used for peptide coupling.

Uses An enzyme inhibitor

Purification Methods It is an excellent H2O-soluble peptide coupling reagent. It is purified by dissolving (ca 1g) in CH2Cl2 (10mL) at room temperature and then add dry Et2O (~110mL) dropwise and the crystals that separate are collected, washed with dry Et2O, recrystallised from CH2Cl2/Et2O and dried in a vacuum over P2O5. It is important to work in a dry atmosphere or work rapidly and then dry the solid as soon as possible. The material is moderately hygroscopic, but once it becomes wet it reacts slowly with H2O. Store it away from moisture at -20o to slow down the hydrolysis process. The free base has b 47-48o/0.27mm, 53-54o/0.6mm, n 1.4582. The methiodide is recrystallised from CHCl3/EtOAc, the crystals are filtered off, washed with dry Et2O, recrystallised from CHCl3/Et2O, and dried in vacuo over P2O5, m 93-95o, 94-95o. [Sheehan et al. J Am Chem Soc 87 2492 1965, Sheehan & Cruickshank Org Synth Coll Vol V 555 1973.] § A polymer bound version is commercially available.

1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride Preparation Products And Raw materials

Preparation Products 6-BROMO-4-CHLORO-2-METHYL-QUINAZOLINE-->6-bromo-2-methylquinazolin-4(3H)-one-->2-AMINO-5-BROMOBENZAMIDE

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Product: 1-(3-Dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride

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