N-Hydroxysuccinimide Chemical Properties | |
Melting point | 95-98 °C(lit.) |
Boiling point | 215.33°C (rough estimate) |
density | 1.4769 (rough estimate) |
refractive index | 1.4080 (estimate) |
storage temp. | 2-8°C |
form | Liquid or Solid |
color | Clear yellow-brown to brown |
PH | 5-7 (50g/l, H2O, 20℃) |
Water Solubility | SOLUBLE |
Sensitive | Hygroscopic |
BRN | 113913 |
Stability: | Stable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, strong bases. Protect from moisture. |
InChIKey | NQTADLQHYWFPDB-UHFFFAOYSA-N |
CAS DataBase Reference | 6066-82-6(CAS DataBase Reference) |
NIST Chemistry Reference | N-hydroxylsuccinimide(6066-82-6) |
EPA Substance Registry System | 2,5-Pyrrolidinedione, 1-hydroxy-(6066-82-6) |
Safety Information | |
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 22-24/25-26-36 |
WGK Germany | 3 |
Hazard Note | Irritant |
TSCA | Yes |
HS Code | 29251995 |
N-Hydroxysuccinimide Usage And Synthesis | |
Chemical Properties | White to pale yellow |
Uses | Reagent for preparation of active esters of amino acids. |
Uses | Useful in the carbodiimide method for improved amidations and peptide couplings. |
Uses | Additive used in the carbodiimide method for improved amidations and peptide couplings. |
Purification Methods | Recrystallise the imide from EtOH/ethyl acetate [Manesis & Goodmen J Org Chem 52 5331 1987]. [Beilstein 21/9 V 498.] |
N-Hydroxysuccinimide Preparation Products And Raw materials | |
Raw materials | Hydroxylamine hydrochloride-->Succinic anhydride |
Preparation Products | Enalapril-->Imidapril-->N-ACRYLOXYSUCCINIMIDE-->Arbekacin-->Aspoxicillin-->GUSPERIMUS |
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