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  • Product Name:   N-Hydroxysuccinimide
  • Synonyms:   N-HYDROXY-2,5-PYRROLIDINEDIONE;NHS;N-HYDROXYSUCCINIMDE;1-hydroxy-5-pyrrolidinedione;1-Hydroxysuccinimide
  • CAS No.:   6066-82-6
  • Molecular Formula:   C4H5NO3
  • Molecular Weight :   115.09
  • Specification :   98%
  • Place of Origin:   China
  • Appearance :   
  • Document :   Download

Description of N-Hydroxysuccinimide



N-Hydroxysuccinimide Chemical Properties


Melting point  95-98 °C(lit.)


Boiling point  215.33°C (rough estimate)


density  1.4769 (rough estimate)


refractive index  1.4080 (estimate)


storage temp.  2-8°C


form  Liquid or Solid


color  Clear yellow-brown to brown


PH 5-7 (50g/l, H2O, 20℃)


Water Solubility  SOLUBLE


Sensitive  Hygroscopic


BRN  113913


Stability: Stable. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides, strong bases. Protect from moisture.


InChIKey NQTADLQHYWFPDB-UHFFFAOYSA-N


CAS DataBase Reference 6066-82-6(CAS DataBase Reference)


NIST Chemistry Reference N-hydroxylsuccinimide(6066-82-6)


EPA Substance Registry System 2,5-Pyrrolidinedione, 1-hydroxy-(6066-82-6)




Safety Information


Hazard Codes  Xi


Risk Statements  36/37/38


Safety Statements  22-24/25-26-36


WGK Germany  3


Hazard Note  Irritant


TSCA  Yes


HS Code  29251995




N-Hydroxysuccinimide Usage And Synthesis


Chemical Properties White to pale yellow


Uses Reagent for preparation of active esters of amino acids.


Uses Useful in the carbodiimide method for improved amidations and peptide couplings.


Uses Additive used in the carbodiimide method for improved amidations and peptide couplings.


Purification Methods Recrystallise the imide from EtOH/ethyl acetate [Manesis & Goodmen J Org Chem 52 5331 1987]. [Beilstein 21/9 V 498.]




N-Hydroxysuccinimide Preparation Products And Raw materials


Raw materials Hydroxylamine hydrochloride-->Succinic anhydride


Preparation Products Enalapril-->Imidapril-->N-ACRYLOXYSUCCINIMIDE-->Arbekacin-->Aspoxicillin-->GUSPERIMUS


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