(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate Chemical Properties | |
Melting point | 163-168 °C(lit.) |
RTECS | TH3890000 |
storage temp. | ?20°C |
form | Powder or Crystalline Powder |
color | White to off-white |
Water Solubility | Soluble in water. |
CAS DataBase Reference | 156311-83-0(CAS DataBase Reference) |
Safety Information | |
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 26-36 |
WGK Germany | 3 |
(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate Usage And Synthesis | |
Chemical Properties | White to off-white crystalline powder |
Uses | Used as a coupling reagent in solid phase peptide synthesis. It is preferred over HATU, because it does not side react at the N-terminus of the peptide. Compared to the HOBt derivates, PyAOP (and HOAt in general) are more reactive due to the additional nitrogen. |
(3-Hydroxy-3H-1,2,3-triazolo[4,5-b]pyridinato-O)tri-1-pyrrolidinylphosphonium hexafluorophosphate Preparation Products And Raw materials | |
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