CAS No:123-99-9 Azelaic acid|1,7-Dicarboxyheptane;azelaic;azelaicacid,technicalgrade;Azelainic acid;Emerox 1110

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Product Name: Azelaic acid
Synonyms: 1,7-Dicarboxyheptane;azelaic;azelaicacid,technicalgrade;Azelainic acid;Emerox 1110
CAS No.: 123-99-9
Molecular Formula: C9H16O4
Molecular Weight : 188.22
Specification : 98%
Place of Origin: China
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Azelaic acid Chemical Properties

Melting point	98 °C

Boiling point	286 °C100 mm Hg(lit.)

density	1,029 g/cm³

vapor density	6.5 (vs air)

vapor pressure	<1 mm Hg ( 20 °C)

refractive index	1.4303

Fp	215 °C

storage temp.	2-8°C

solubility	2.4g/l

form	Slightly Crystalline Powder or Flakes

pka	4.53, 5.33(at 25℃)

color	White to slightly yellow

PH	3.5 (1g/l, H2O)

Water Solubility	2.4 g/L (20 ºC)

Merck	14,905

BRN	1101094

Stability:	Stable. Combustible. Incompatible with bases, strong oxidizing agents. Readily biodegrades in soil and water with >70% DOC reduction after 28 days.

CAS DataBase Reference	123-99-9(CAS DataBase Reference)

NIST Chemistry Reference	Nonanedioic acid(123-99-9)



Azelaic acid Usage And Synthesis

Chemical Properties	white to cream solid

Uses	antiacne, antiproliferative agent

Uses	antifungal, binds to membrane sterols

Brand name	Azelex (Allergan); Finacea (Intendis).

Purification Methods	Recrystallise it from H2O(charcoal) or thiophene-free *benzene. The acid can be dried by azeotropic distillation with toluene, the residual toluene solution is then cooled and filtered, and the precipitate is dried in a vacuum oven. It has been purified by zone refining or by sublimation onto a cold finger at 10-3torr. It distils above 360o with partial formation of the anhydride. The dimethyl ester has m –3.9o and b 140o/8mm. [Hill & McEwen Org Synth Coll Vol II 53 1943, Beilstein 2 IV 2055.]



Azelaic acid Preparation Products And Raw materials

Raw materials	1,5-Pentanedioic acid-->Ozone-->1,5-Dibromopentane-->Dimethyl azelate

Preparation Products	Misoprostol-->CYCLOOCTANONE-->AZELAIC ACID DI(2-ETHYLHEXYL) ESTER-->trans,trans-2,4-Nonadienal-->FEMA 3377-->AZELANITRILE

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