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  • Product Name:   3-Nitrophenol
  • Synonyms:   3-Hydroxy-1-nitrobenzene;M-NITROPHENOL;M-NITROPHENOL INDICATOR;1-Hydroxy-3-nitrobenzene;3-Hydroxynitrobenzene
  • CAS No.:   554-84-7
  • Molecular Formula:   C6H5NO3
  • Molecular Weight :   139.11
  • Specification :   98%
  • Place of Origin:   China
  • Appearance :   
  • Document :   Download

Description of 3-Nitrophenol
3-Nitrophenol Chemical Properties
Melting point  89-95 °C
Boiling point  194 °C70 mm Hg(lit.)
density  1,49 g/cm3
refractive index  1.5723 (estimate)
Fp  102°C
storage temp.  Store at +5°C to +30°C.
solubility  13.5g/l insoluble
pka 8.28(at 25℃)
form  Crystalline Powder
color  Yellow to brown
PH Range 6.6(colourless)-8.6(yellow/orange)
PH 6.6-8.6 (H2O, 20℃)
Water Solubility  13.5 g/L (25 ºC)
λmax 570nm
Merck  14,6618
BRN  1907946
Major Application Display device, semiconductor device, sensors, high voltage capacitors, energetic materials, electrolyte batteries, inks, correction fluid, detergent, leak detection method, lubricants, insecticide, food storage, inhibition of amyloidoses, detect bacterialinfection, drugs, material for evaluating dental caries activity
InChIKey RTZZCYNQPHTPPL-UHFFFAOYSA-N
CAS DataBase Reference 554-84-7(CAS DataBase Reference)
NIST Chemistry Reference Phenol, 3-nitro-(554-84-7)
EPA Substance Registry System Phenol, 3-nitro-(554-84-7)
Safety Information
Hazard Codes  Xn,Xi
Risk Statements  22-38-41-36/37/38-33-20/21/22
Safety Statements  26-36/37-45-36/37/39-22-28
RIDADR  UN 1663 6.1/PG 3
WGK Germany  3
RTECS  SM1925000
F  8
Hazard Note  Harmful/Irritant
TSCA  Yes
HazardClass  6.1
PackingGroup  III
HS Code  29089000
Hazardous Substances Data 554-84-7(Hazardous Substances Data)
Toxicity LD50 orally in mice, rats: 1414, 933 mg/kg, K. C. Back et al., Reclassification of Materials Listed as Transportation Health Hazards (TSA-20-72-3; PB214-270, 1972)
3-Nitrophenol Usage And Synthesis
Chemical Properties yellow to brown crystalline powder
Uses 3-Nitrophenol is a chemical reagent used in various organic syntheses. Used in the synthesis of RAGE inhibitors via the etherification of phenols. Also used in the synthesis of kinase inhibitors again st epidermal growth factor receptor T790M mutation.
Definition ChEBI: A member of the class of 3-nitrophenols that is phenol in which one of the hydrogens that is meta to the hydroxy group has been replaced by a nitro group.
Uses As indicator in 0.3% solution in 50% alcohol. pH: 6.8 colorless, 8.6 yellow.
General Description Colorless to pale yellow crystalline solid. Sinks in and mixes with water.
Air & Water Reactions Water insoluble.
Reactivity Profile 3-Nitrophenol is a light-yellow, crystalline material, toxic and irritant. When heated to decomposition 3-Nitrophenol emits toxic fumes of oxides of nitrogen [Lewis, 3rd ed., 1993, p. 941]. Phenols do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has Ka = 1.3 x 10^[-10]). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases.
Health Hazard INHALATION: Inhalation or ingestion causes headaches, drowsiness, nausea, and blue color in lips, ears, and finger nails (cyanosis). EYES: Contact with eyes causes irritation. SKIN: Can be absorbed through intact skin to give same symptoms as for inhalation.
Fire Hazard Special Hazards of Combustion Products: Dangerous toxic fumes of NO x
Purification Methods Crystallise 3-nitrophenol from water, CHCl3, CS2, EtOH or pet ether (b 80-100o), and dry it under vacuum over P2O5 at room temperature. It can also be distilled at low pressure. The 4-nitrobenzoate had m 174o (from EtOH). [Beilstein 6 IV 1269.]
3-Nitrophenol Preparation Products And Raw materials
Preparation Products m-Anisidine-->2,5-DINITROPHENOL-->3,5-DINITROPHENOL
Raw materials 3-Nitroaniline

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