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  • Product Name:   4-Cyanophenylboronic acid
  • Synonyms:   CHEMBRDG-BB 3200965;4-CYANOBENZENEBORONIC ACID;AKOS BRN-0076;RARECHEM AH PB 0209;P-CYANOPHENYLBORONIC ACID
  • CAS No.:   126747-14-6
  • Molecular Formula:   C7H6BNO2
  • Molecular Weight :   146.94
  • Specification :   98%
  • Place of Origin:   China
  • Appearance :   
  • Document :   Download

Description of 4-Cyanophenylboronic acid
4-Cyanophenylboronic acid Chemical Properties
Melting point  >350 °C(lit.)
storage temp.  0-60°C
form  Powder
color  White to yellow
BRN  6593772
CAS DataBase Reference 126747-14-6(CAS DataBase Reference)
Safety Information
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  22-24/25-37/39-26-36
RIDADR  UN3439
WGK Germany  3
Hazard Note  Irritant
HazardClass  6.1
PackingGroup  III
4-Cyanophenylboronic acid Usage And Synthesis
Description 4-Cyanophenylboronic acid can be used for palladium catalyzed Suzuki cross-coupling reactions to synthesize 6-acryl-2,4-diamino-pyrimidines and triazines. It is used as precursor in the synthesis of inhibitors such as Tpl2 kinase inhibitors and P2X7 antagonists used in the treatment of pain. It is also a reagent used for preparation of himbacine analogs as thrombin receptor antagonists and potential antiplatelet agents, trisulfonated calixarene upper-rim sulfonamido and their complexation with trimethyllysine epigenetic mark, antimalarial compounds via Suzuki cross-coupling, and deoxyuridine derivatives.
Reference
  • G. Cooke, H. A. de Cremiers, V. M. Rotello, B. Tarbit, P. E. Vandersträten, Synthesis of 6-aryl-2,4-diamino-pyrimidines and triazines using palladium catalysed Suzuki cross-coupling reactions, Tetrahedron, 2001, vol. 57, pp. 2787-2789
  • N. Ni, H. Chou, J. Wang, M. Li, C. Lu, P. C. Tai, B. Wang, Identification of boronic acids as antagonists of bacterial quorum sensing in Vibrio harveyi, Biochemical and Biophysical Research Communications, 2008, vol. 369, pp. 590-594
Chemical Properties white to yellow powder
Uses suzuki reaction
Uses Intermediates of Liquid Crystals
4-Cyanophenylboronic acid Preparation Products And Raw materials
Raw materials Tetrahydrofuran-->n-Butyllithium-->Nitrogen-->Trimethyl borate-->4-Bromobenzonitrile

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